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For retatrutide (6-day half-life), 24-30 days

Quick Answer: You can technically take GLP-1 and berberine together, but because both lower blood sugar and cause digestive upset, you must consult a licensed provider to avoid hypoglycemia and severe gastrointestinal distress

doi: 10.1002/14651858.CD012691

The general class of GLP-1 drugs targets at least one of the reactions

Patients are commonly prescribed subcutaneous injections, but a daily, oral formulation of semaglutide now exists