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In overweight humans, liraglutide 3 mg solidly inhibits gastric emptying after 5wk of treatment, but the efficacy markedly decreases after 16wk of treatment, yet with still significant effect relative to placebo treated controls [808]

Melanie Jay, who directs the Comprehensive Program on Obesity at NYUs Langone Medical Center

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Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits

This happens because the body fights weight loss by: Increasing hunger hormones Reducing metabolism Increasing cravings Conserving calories Obesity is therefore a biological disease rather than a simple lifestyle issue