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Thus, recent ADA and CDC guidelines have recommended use of GLP-1RAs for treatment of T2D patients with high risk of atherosclerosis and coronary heart disease

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It is known that the CV protection effect of GLP-1RAs have been proven through eight large-scale clinical studies, including Evaluation of LIXisenatide in Acute coronary syndrome (ELIXA) [66], LEADER [44], Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN)-6 [67], Exenatide Study of Cardiovascular Event Lowering (EXSCEL) [68], Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes) [69], Researching Cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) [70], Peptide Innovation for Early Diabetes Treatment (PIONEER) 6 [67,71], and AMPLITUDE-O [51]

Eligibility thresholds vary based on the medication and the type of help: Manufacturer PAPs: Typically look for income below $31,300 (single) or $42,300 (married) for certain medications like Ozempic

however, as mentioned, studies aiming at intensified control have often been disappointing