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Tan TMM, Minnion J, Khoo B, Ball LJ, Malviya R, Day E, et al

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Can I take something by mouth, fit it around normal meals, afford it, and live with the side effects long enough for it to help

Comparison with the binding modes of other dual and triple agonists highlight that the N-terminal and C-terminal regions of the peptide confer receptor selectivity, whereas the middle region offers opportunities for sequence optimization to refine receptor engagement, thereby presenting a useful template for designing better unimolecular therapeutics

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When adverse effects mirror the peptides known physiological actions rather than off-target toxicity, the appropriate response may be signal bias or contextual restriction rather than target rejection