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Advert That's more than Mounjaro, which during clinical trials was found to lead to an average of 26.6 percent weight loss over 84 weeks, and Wegovy, which was found to help patients lose 19 percent of their body weight over 72 weeks

The mechanism is generally telogen effluvium driven by rapid weight loss rather than a direct effect of tirzepatide, similar to what is seen after bariatric surgery or any aggressive caloric deficit

[Crossref] Marathe C, Rayner C, Wu T, Jones K, Horowitz M (2018) Gastric emptying and the personalized management of type 1 diabetes

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Because the incidence of AEs was greatest during dose escalation, the disparity in total years of exposure between the two trials could potentially dilute the reported rate of AEs in PIONEER 3 compared with PIONEER 12

So whether NAD nasal spray is effective for energy or aging is an open research question, and results vary from person to person
