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Glucagon-like peptide 1 (GLP-1) is an incretin 30 amino-acid peptide hormone produced in hindbrain neurons and in specialized enteroendocrine cells (L cells) in the distal small and large intestines that is released after food intake [23, 24]

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Phase III results for retatrutide are set to be released later in 2025 and in early 2026, but an earlier phase II trial recorded between a 7.2% and 17.5% reduction in body weight after 24 weeks, depending on the dose (7.2% on 1mg, 17.5% on 12mg), and up to a 24.2% reduction in body weight after 48 weeks for those on 12mg (-8.7% change for those on 1mg) 8

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doi: 10.1530/JOE-24-0210 67 AkyayOZCanturkZSelekACetinarslanBTarkunCakmakYet al

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Identifying clusters of patient comorbidities associated with obstructive sleep apnea using electronic health records

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PharmEasy does not make any representation on the accuracy or suitability of such products/services

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What's Next in the Triple Agonist Research Pipeline Beyond retatrutide, other triple agonist candidates are in earlier-stage clinical development

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