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Although the exact mechanisms by which the coordinated actions of GLP-1 receptor agonism and NMDA receptor antagonism correct metabolic diseases await further elucidation, the extensive alterations in transcriptomic and proteomic responses within the hypothalamus, linked to glutamatergic signalling and synaptic plasticity, imply that the conjugate might elicit neurostructural changes in GLP-1-receptor-expressing neurons

[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Berenbaum F

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Body Composition Findings Data suggests weight reduction is largely derived from fat mass, with comparatively limited lean muscle loss

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