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how long have glp 1 drugs been around Research shows GLP-1 are effective but complex GLP-1 Drug Market: the rapid
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BMJ (2015) 350:g7607

For patients with advanced metabolic dysfunction, fatty liver disease, or those seeking maximal weight loss, retatrutide may become the gold standard therapy offering results previously only attainable through surgery
Zhang, L., Zhang, W

The side effect comparison between semaglutide and tirzepatide shows broadly similar profiles with slightly lower severity for semaglutide at equivalent therapeutic doses

10.1016/S0140-6736(18)32261-X 47

This is where I think the best path forward is to present several theories, which Im listing roughly from plausible to speculative