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Researchers analysed six years of data from more than 16,800 neuro-opthalmology patients and found that the risk of NAION occurring for the first time over a 36-month time period was 8.9% among patients with T2DM who had been prescribed semaglutide (n=194), compared with 1.8% in 516 patients with T2DM prescribed other antidiabetic medicines

Hyperlipidemia associated with atherosclerosis affecting retinal circulation

Note that the participants were unaware that any reward contingency reversals would occur

Thyroid Conditions : Semaglutide may increase the risk of certain thyroid tumors in animal studies, though human evidence is less clear

The explanation fits the overall picture: it is not the amount of drug that decides things, but how much weight comes off in the end

As the body adjusts to the medication, symptoms like tingling and tenderness tend to fade