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The decision to use both medications should follow NICE guidance for weight management (TA664) and thyroid disorder management (NG145), with clear therapeutic goals established at the outset

After 28 days, the medication should be discarded even if it appears clear and colorless

Patients are advised to inject Wegovy on the same day each week, at any time of the day, with or without meals

Long-term therapy decisions should weigh oncological efficacy against risks of endometrial cancer, thromboembolism, and metabolic alterations

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, Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial