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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial
The underlying mechanisms of cardiovascular and renal protection differ partially between GLP1-RAs (mainly anti-atherogenic and vascular effects) and SGLT2is (primarily systemic and intrarenal hemodynamic changes)

In a clear attempt to make the price tag of GLP-1 drugs more palatable, drugmakers are promoting their other health advantages
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These trends are consistent with first-time prescribing rates seen around the holidays in previous years
Marx N, et al

doi: 10.1136/ard.2004.031740