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Renoprotective effects of GLP-1 receptor agonists: clinical trials The first clinical evidence for beneficial effects of GLP-1 receptor agonists came from the cardiovascular outcome trials (CVOTs) that were conducted with these agents, where kidney endpoints were collected as secondary or exploratory endpoints

The most recently marketed Tirzepatide targets not only the GLP-1 receptors, but also the Glucose-dependent Insulinotropic Polypeptide (GIP) receptors, which have similar important functions in blood glucose regulation

For patients with insurance that covers obesity medications, this approach can help to reduce the overall treatment costs

When surgery is delayed or cancelled due to concerns about gastric emptying, hospitals incur financial loss through wasted operating time and resource reallocation

Potential protective effects may arise from multiple mechanisms, including the complex interplay between weight stigmatization, psychological distress, and improvements in overall health and self-perception among adolescents ( 15 , 16 )

Clinical efficacy of sodium-glucose cotransporter 2 inhibitor and glucagon-like peptide-1 receptor agonist combination therapy in type 2 diabetes mellitus: real-world study