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Norn GN, Hopstadius J, Bate A

McGill et al., Long-Term Efficacy and Safety of Linagliptin in Patients With Type 2 Diabetes and Severe Renal Impairment, Diabetes Care, vol

Understanding this helps explain why most side effects are gastrointestinal, why they're dose-dependent, and why they usually improve with time

Large clinical trials have demonstrated their effectiveness, and they are now increasingly prescribed for diabetes and weight management

Diabetes Care 39:20422050 Inzucchi SE, Zinman B, Fitchett D, Wanner C, Ferrannini E, Schumacher M et al (2018) How does empagliflozin reduce cardiovascular mortality

But no medication is perfect, and some people have been disappointed with the drugs or say the side effects aren't worth it