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Can I switch between semaglutide and tirzepatide if I'm not tolerating one

N Engl J Med 2021;385:896-907.ArticlePubMed 72

A 2024 KFF survey revealed that about 1 in 8 American adults have tried a GLP-1 agonist, which works by mimicking a natural hormone in the body that regulates insulin and blood sugar levels while promoting feelings of fullness, helping the average patient shed 10% to 15% of their body weight

There are clear situations where it makes more sense than tirzepatide, and dismissing it entirely because tirzepatide produces more weight loss would be a mistake

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

These findings support the therapeutic potential of both drug classes, individually or combined, in PCOS management, providing a foundation for more personalized treatment approaches