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Eli Lilly's obesity pill, orforglipron, had a 12.4% average weight loss at its highest dose over 72 weeks, which means it's less effective than injections on the market

GLP-1s were associated with a significant reduction in body weight in 15 studies and improved glycemic control in eight studies enrolling people with mental illness

However, this approach must be considered as an add-on rather than an alternative to the search for novel drugs

Bone Metab

Massachusetts General Brigham researchers found that GLP-1s can reduce muscle and bone tissue, leading to ketosis (loss of muscle mass), which is particularly dangerous for older adults

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