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Patient enrollment in clinical studies is also based mainly on baseline A1C, and treatment of a comparator is sometimes chosen unrelated to its pathophysiologic effect on hyperglycemia

Randomised controlled trials have demonstrated statistically significant reductions in visceral adipose tissue (VAT) compared to placebo, with improvements in lipid profiles also reported

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This might involve optimising other oral medications, considering alternative injectable therapies, or intensifying lifestyle interventions

I used to love lifting heavy weights, but because I've had a stroke and other health issues, I can't do those things

This interaction matters because patients starting compounded semaglutide often experience dose-dependent GI sensitivity