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Some concerns have arisen due to animal studies where semaglutide was linked to an increased risk of thyroid tumors in rodents

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Baseline characteristics included a mean age of 48 years, 71% female, 72% White, 14% Asian, 9% Black or African American, and 5% reported as other or unknown

As a widely used hypoglycemic drug in clinical practice, semaglutide not only regulates glucose metabolism but presents anti-inflammatory, autophagy-regulating and mitochondrial biogenesis-regulating effects, and it has also been reported to alleviate oxidative stress and improve skeletal muscle mass, all these effects independently of body weight reduction

Nevertheless, the findings suggest that GLP1 may have favorable effects in these male patients, particularly in obese and metabolically complicated men

0.9% on placebo) 4.3% discontinued treatment due to GI events These numbers are reassuring