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One of them was called exendin-4 and it bore a striking similarity structurally and functionally to a human protein, called glucagon like peptide-1 (or GLP-1)

Benefits for SGLT-2 inhibitors and GLP-1 receptor agonists on the absolute scale were largest for those with heart failure, chronic kidney disease, or those using mineralocorticoid receptor antagonists

doi: 10.1186/s12906-017-1667-6 Glossary Summary Keywords diabetes mellitus, antidiabetic, antihyperglycemic, phytochemical, phytomedicine, bioactive compound, drug discovery, drug development Citation Alam S, Sarker MMR, Sultana TN, Chowdhury MNR, Rashid MA, Chaity NI, Zhao C, Xiao J, Hafez EE, Khan SA and Mohamed IN (2022) Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development