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As the global prevalence of AD continues to rise, especially among postmenopausal women, dual agonism targeting estrogen and GLP-1 receptors may represent a novel, physiologically informed approach to prevention and intervention

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Up to 75% of adults will experience hemorrhoids by age 50, with pregnancy, chronic constipation, and prolonged sitting increasing risk due to increased pressure on anal veins

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These include the hypothalamus, VTA, and nucleus accumbens
