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These changes often include: More visible cellulite Looser or deflated appearance of the thighs Reduced volume in the legs Skin that appears uneven or creased Areas where fat loss unmasks existing skin quality issues These changes are common and rooted in predictable physiology, not a sign of something wrong. Understanding why they happen can help you make informed, empowered decisions about your body and your options

[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Han VKM, Hynes MA, Jin C, Towle AC, Lauder JM, Lund PK

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One additional result of this study was a reduction in smoking for those who used cigarettes

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Your provider will monitor tolerability, glycemic response (if applicable), and weight loss trajectory over 8-12 weeks before dose escalation