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Diab Care 38:18271834

Subtle conformational dynamics allow the C-terminus of GLP-1 to access the ECD binding site, and the ligand binding triggers further dissociation of the ECD from the TMD allowing the N-terminus of GLP-1 to enter the orthosteric pocket in the TMD and activate the receptor

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Peters H, Potla P, Rockel JS, Tockovska T, Pastrello C, Jurisica I, et al