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The number of treatment-emergent adverse events (TEAEs) during exposure to treatment was the primary outcome in the Japanese safety study, PIONEER 10

Graphical abstract Lee J, Hong SW, Kim MJ, Moon SJ, Kwon H, Park SE, Rhee EJ, Lee WY

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Alternative options include NHS lifestyle programmes at no cost, Orlistat (20-40 monthly), Wegovy (150-250 monthly), and bariatric surgery for eligible patients

Additionally, quantitative evaluation of mitophagic flux using the MT-Keima probe and flow cytometry indicated that CGA significantly enhanced mitophagy relative to cells exposed solely to H 2 O 2 (Figures 4I,J)