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Abbreviations ABC ATP-binding cassette ABCA1 ATP-binding cassette transporter A1 GLP-1 glucagon-like peptide-1 GSIS glucose-stimulated insulin secretion HDL high-density lipoprotein HDL-C high-density lipoprotein cholesterol H&E Hematoxylin and eosin IHC immunohistochemical IP immunoprecipitation LDL low-density lipoprotein LSG laparoscopic sleeve gastrectomy LXR liver X receptor OGTT oral glucose tolerance test PARP poly ADP-ribose polymerase RCT reverse cholesterol transport RYGB Roux-en-Y gastric bypass STZ streptozotocin TC total cholesterol TG total triglyceride T2DM type 2 diabetes

Neuromolecular Med (2014) 16(2):38997.10.1007/s12017-013-8286-2 44 DalleyJWRoiserJP

Consumption of ultra-processed foods associated with weight gain and obesity in adults: A multi-national cohort study

Figure from Rossing et al NDT 2023 Primary Outcome This was a composite of time of first occurrence of: Onset of kidney failure (persistent eGFR 28 days or initiation of long-term KRT, kidney transplantation) Persistent 50% reduction in eGFR from baseline Death from kidney or CV causes Secondary Outcomes Confirmatory secondary outcomes were analyzed hierarchically

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Its also the name given to semaglutide, a weight loss medication that mimics that hormone