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Effect of subcutaneous tirzepatide vs placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: The SURPASS-5 randomized clinical trial

The needles used are very fine, and many patients report minimal discomfort

For semaglutide, the target dose for weight management is 2.4 mg weekly

Hormone-sensitive lipase (HSL) in adipocytes is activated to produce the lipolytic effect, which is then enhanced by indirect processes such as secretion of growth hormone, cortisol, and adrenaline [39]

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Second, although this analysis included 45 studies with a fairly large sample size, the low incidence of thyroid events resulted in a wide confidence interval that reduced the certainty of our findings