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Interruptions in therapy, whether due to financial constraints, insurance issues, or drug shortages, can complicate treatment and increase the risk of GI AEs when therapy is resumed at the previous dose

DOI: 10.1056/NEJMoa2500969

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Combination of oligofructose and metformin alters the gut microbiota and improves metabolic profiles, contributing to the potentiated therapeutic effects on diet-induced obese animals

When other efforts fail, glucagon-like peptide-1 (GLP-1) drugs, such as Ozempic and Wegovy, may be able to help

It's also worth noting that the GLP-1 bone story isn't uniformly negative in the research
