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A precision adjunct framework reconceptualises curcumin as a formulation-dependent pharmacological entity

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Trial participants with diabetes achieved 19.7% weight loss plus 2.02% A1C reduction on average

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Both drug classes lower glucose concentrations (though through distinct mechanisms) without excess risk for hypoglycaemia, reduce body weight and albuminuria and prevent cardiovascular events, but they have opposing effects on glucagon secretion which is augmented by SGLT-2 inhibitors but suppressed by GLP-1 receptor agonists