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Aminoisobutyric acid (Aib) substitutions at positions 2 and 13 confer resistance to DPP-4 cleavage the enzyme that inactivates native GIP and GLP-1 within minutes

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To view or add a comment, sign in Fascinating article from past and future #FewAndFarBetween guest, Justin Stebbing and colleagues arguing that GLP-1 drugs mark the beginning of systems medicine, not "just" a weight-loss revolution

Persistent high glucose levels increase islet amyloid polypeptides (IAAP) and proinsulin production, resulting in misfolded insulin and IAAP accumulation, and elevated reactive oxygen species (ROS) [14]
