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Engineering new ligands that specifically target multiple G protein-coupled receptors with desired activity profiles requires time-consuming and expensive cycles of design-make-test-analyse work

Chronic diseases such as obesity and diabetes, cardiovascular and inflammatory bowel diseases (IBD) share common features in their pathology

The pharmaceutical boom in weight-loss drugs has put companies like Novo Nordisk and Eli Lilly in ever-fiercer competition

However, the current literature reveals a lack of in vivo studies on specific GLP-1R agonists such as semaglutide, necessitating further research to elucidate its precise mechanisms and effects, particularly in cancer

Learn what patients and prescribers should know about lean mass, protein, and exercise.

David Kessler says the new weight-loss drugs are a powerful tool to fight obesity