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Patients were randomized (1:1:1:1) by using an interactive web-response system to once a week treatment with either semaglutide 0.5 mg, dulaglutide 0.75 mg, semaglutide 1.0 mg, or dulaglutide 1.5 mg subcutaneously

These effects are mild to moderate in most patients and do not prevent weight loss

This schedule was validated in the SURMOUNT clinical trial program, which demonstrated average weight loss of 20 to 25 percent of body weight over 72 weeks at the highest doses

Weight loss and safety outcomes were consistent with those in semaglutide clinical trials, losing 16.6% of their weight in 68 weeks

When retreatment effects produced clinical values (eg, BMI, HbA1c, or SBP) that exceeded plausible ranges for the general patient population, effect sizes were capped at the minimum or maximum effect observed after the initial administration

Why Skin Laxity Happens After Rapid Weight Loss Skin is supported by a network of collagen, elastin, and underlying fat