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Conversely, transgenic mice overexpressing Gipr show enhanced exploratory behavior, increased motor performance and improved working memory [1062], while treatment of wildtype mice or rats with [D-Ala 2 ]GIP enhances learning, synaptic plasticity and neurogenesis in the hippocampus [923,1063]

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In an additional, 24-week, placebo-controlled factorial study of initial therapy with sitagliptin in combination with metformin, the adverse reactions reported (regardless of investigator assessment of causality) in 5% of patients are shown in Table 2