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The goal is not to suppress every episode at any cost but to keep the patient on the medication through the adaptation window

No dose adjustment is required for hepatic impairment, though limited data exists for severe cirrhosis and specialist input should be sought for decompensated disease

These results led to an ongoing phase-II, randomized, sham surgery controlled, double-blind, multi-center clinical trial (NCT03562494, Table 1) to primarily assess changes in ON-time duration without dyskinesias, as recorded by participants in their PD diary

Sleep tuning: Set a consistent bedtime within a 60-minute window Limit bright screens 30 to 60 minutes before bed Use short naps (20 minutes) only when nighttime sleep is short Recovery also responds to predictable rhythms, so keeping training intensity steady across weeks is better than sporadic extremes