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The beneficial effects of GLP-1 RAs on HRQoL and other outcomes in HFpEF are likely due to pleiotropic impacts, related or not to weight reduction, such as decongestion (mainly due to the reduction of increased plasma volume associated with obesity and epicardial constrain), reverse cardiac remodelling (mainly due to the decrease in epicardial fat and regression of left atrial and LV myopathy, lowering intracardiac pressure) and anti-inflammatory actions, among others

Heres What Experts Say Although it doesn't impact everyone in the same way, some patients report feeling sluggish

They can help improve symptoms of depression, anxiety and emesis but also diminish the function of contraceptives

6 Data from CV outcome trials have also demonstrated that GLP-1 RAs can reduce atherosclerotic events, particularly in patients with established or a high risk of CVD

PlexusDx Precision Peptide Genetic Test ($99 add-on after the first month) maps 14 weight-regulation pathways across 49 peptides and 150+ genetic insights, including key variants such as GIPR rs1800437, GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313

Patients should contact their GP or diabetes specialist nurse within a few days if they notice: new or worsening right upper abdominal discomfort