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45 In that trial, patients receiving semaglutide experienced greater reductions in weight (estimated difference 10.7%

Saxagliptin: A new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus

These results suggest PI3K/Akt/mTOR signaling mediated the protection of GLP-1 on apoptosis in neurons (193)

M., Gratzl S., et al., Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity, JAMA Internal Medicine 184 (2024): 10561064

This could widen health disparities, since adolescents from under-resourced families already have lower access to specialty obesity care (43)

Treatments must align with metabolic physiology, behavioural science, and sustainable lifestyle adjustments to achieve real, lasting results