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Search items included medication-related itemsGLP-1 receptor agonist, GLP-1RA, dual-agonist, and glucagon-like peptide-1 along with cardiovascular outcome-related items major adverse cardiovascular event, myocardial infarction, coronary artery disease, peripheral arterial disease, heart failure, hypertension, and atrial fibrillation. Studies were meticulously screened and included if they reported cardiovascular outcomes related to MACE, myocardial infarction (MI), CAD, PAD, HF, hypertension (HTN), or AF

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The convenience and ease of use of orforglipron will most likely enhance patient adherence and broaden the appeal of GLP-1 therapies to individuals who were previously hesitant about injectable treatments
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