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As a general guideline, Semaglutide GLP-1 injections are typically prescribed to individuals with a BMI of 30 or above or 27 and above with at least one weight-related condition, such as high cholesterol, osteoarthritis, or sleep apnea

GLP-1 medications carry a boxed warning for thyroid C-cell tumors (medullary thyroid carcinoma) based on rodent studies, though no conclusive increase in human cases has been established

Lancet Diabetes Endocrinol 2014;2:464473

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In a model of lipopolysaccharide (LPS)-induced visceral hypersensitivity and repeated water deprivation stress in rats, liraglutide reduced visceral allodynia by inhibiting proinflammatory cytokine production and attenuating intestinal permeability [54]

A history of pancreatitis also raises concern