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publicly available FDA regulatory communications

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We used basal insulin as an active comparator to GLP-1RAs, as both GLP-1RAs and basal insulin are recommended as second-line therapies for type 2 diabetes by Danish national guidelines [16]

Furthermore, even in countries with better economic situations, medical insurance agents demand evidence for long-term efficacy and safety

To illustrate the value of a biosimilar in this space, Biogen referenced in its press release a report by the Association for Accessible Medicines which states that spending on therapies for autoimmune diseases has consistently increased by 10% to 25% each year over the past decade

Given that GLP-1RA may increase the risk of certain tumors or promote the proliferation of certain tumor cells, the treatment plan can be adjusted