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If a peptide has approximately 30 percent sublingual bioavailability, you need roughly three times the injectable dose to achieve comparable blood levels

Together, these data suggest that GLP1 receptors are sufficient to mediate all the effects of GLP1, but the effects of endogenous GLP1 on eating behaviour are: (1) compensated for in the knockout mice by functionally overlapping/redundant mechanisms

Direct head-to-head studies are the cleaner way to answer that question

10.1111/j.1460-9568.1995.tb00650.x 76

2 Since it is non-peptide, orforglipron avoids GI degradation barriers that limit peptides, thereby enabling once-daily administration while maintaining efficacy on glucose control, body weight, and tolerability

The market is there, it's growing, companies will benefit," Kaganoff said