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doi: 10.1172/JCI186652 47 GuarnottaVBiancoMJVigneriEPantoFLo SassoBCiaccioMet al
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Interpreting findings from such designs can be difficult, as they are more susceptible to bias and confounding, and feature small sample sizes, limiting the ability to establish causality
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They may also evaluate for reflux, medications that interact, metabolic causes, or neurologic issues when hiccups do not resolve
