bad side effects of glp 1 Comparative safety and semaglutide and tirzepatide: Implications for clinical decision-making in obesity management 7 Weird GLP-1 Side Effects

### Competing Interest Statement ASK, AMM, MCG, JMD, CB, CL, SWB, DJL, PML, DRD, JMC, JPF, YL, ARS, DAT, DWP, SH, RBR, MSL, and DAG are employees and stockholders of Pfizer Inc

The development of multi-agonists with multi-organ targets may alter the natural history of these diseases

GLP-1 receptor (GLP-1R) agonists applied peripherally or centrally decrease food intake and increase glucose-stimulated insulin ...

GLP-Pre is formulated with essential prebiotics that act as food for GLP-1 producing cells in the gut

To help optimize results, experts recommend a whole-food, plant-based diet rich in fiber, lean proteins and healthy fats

Why this matters: Earlier single-center data suggested a higher risk (HR ~ 4.3), but larger, more representative analyses now paint a more reassuring picture