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The cohort excludes any person with no diagnosis, procedure, or pharmacy claims of any kind in the prior 12 months for stability

doi: 10.4158/EP09104.CRR

Glp-1 Supplement Regional Outlook North America GLP-1 Supplement Market North America: Market Dominance Led by Advanced Pharmacy Retail Infrastructure and Supporting Strong Demand for Protein, Hydration, and Digestive-Support Supplements The North America GLP-1 supplement market accounted for the largest regional share of 41.32% in 2025 due to GLP-1 prescription growth, advanced pharmacy retail infrastructure, and increasing demand for companion metabolic nutrition products

Similarly, selective rescue of the GLP-1R in this hypothalamic neuronal population of Glp1r / mice restored an anorexigenic response to GLP-1R agonism, evident following acute liraglutide administration (12)
The important factor to remember is that both medications and supplements are altering the hormones that signal to your brain to stop eating when you are full

Safety and tolerability of sitagliptin in clinical studies: A pooled analysis of data from 10,246 patients with type 2 diabetes
