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Long periods of fasting without sufficient protein intake or dietary variety can lead to nutritional inadequacy, clinical nutrient deficiencies, loss of fatfree mass, and reduced resting energy expenditure [297]

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Dose titration of GLP-1 receptor agonists should follow manufacturer recommendations, typically starting at the lowest dose and increasing gradually every 4 weeks based on tolerability and glycaemic response

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These are typically temporary and often dose-dependent, meaning they can improve over time or with a dosage adjustment