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Therefore, practitioners must recognize early non-responsedefined as less than 2% weight loss within four weeksas a reliable predictor warranting prompt medication consideration
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Their primary mechanisms of action include: Stimulating insulin secretion in a glucose-dependent manner (reducing hypoglycaemia risk) Suppressing glucagon release when blood glucose is elevated Slowing gastric emptying, which prolongs satiety Acting on appetite centres in the brain to reduce food intake Common GLP-1 medicines available in the UK include semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity)
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However, according to a research letter from the JAMA Health Forum, its use is declining
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