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Urinary retention is rare and primarily observed in men with pre-existing BPH (benign prostatic hyperplasia)

studies in rodents published in 1996 demonstrated that intracerebroventricular injection of GLP-1 had a marked effect in both fasting and fed states, and a publication in 1995 showed that a rodent tumor model that produced glucagon and GLP-1 was associated with severe anorexia (178, 179)

Current guidance recommends waiting at least 7 days after your last injection before starting tablets

Where payers and employers are looking From the payer perspective, GLP-1s are both promising and risky

They are a critical part of the drugs stability

Who should be on a GLP-1