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Compared to Phentermine alone, Tirzepatide showed significant associations with reduced oculomotor binocular dysfunction (HR 0.44, 95% CI: 0.280.67, p = 1.3 10 4 ), visual issues and blindness (HR 0.51, 95% CI: 0.350.74, p = 2.8 10 4 ), dry eye disease (HR 0.46, 95% CI: 0.270.79, p = 0.004), ametropic accommodative dysfunction (HR 0.44, 95% CI: 0.280.68, p = 1.9 10 4 ), and visual disturbances (HR 0.45, 95% CI: 0.310.68, p = 7 10 5 )

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N Engl J Med 2016;375:31122

[Accessed 9th July 2026].

5, Panel A)
