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[2] Traditional oral agents remain important options: Metformin continues as first-line therapy for most patients, though it can cause gastrointestinal symptoms initially

Sethi and others have demonstrated safety and efficacy in mixed psychiatric populations, including depression and bipolar disorder and schizophrenia

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Rectal bleeding is relatively common, affecting up to 1334% of individuals at some point in their lives, although less than half of those affected seek medical care
