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Liraglutide attenuates the inflammatory response by inhibiting IKK-/NF-B, thereby reducing islet -cell apoptosis
Patients treated with GLP-1 therapies were experiencing significant weight reduction, sometimes exceeding 15% of body weight in clinical studies when combined with lifestyle changes
Therefore, GLP-1RAs need to pass through the blood-brain barrier to exert their pharmacological effects
And the difference between them is the useful part
Cell Reports , 35 (8)
