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Most patients naturally reduce their protein intake along with overall calories, but protein requirements actually increase during rapid weight loss

To help manage fatigue while on semaglutide: Stay well hydrated to counteract dehydration

Monitoring : Regular monitoring of blood glucose levels, hemoglobin A1c labs, weight loss, and any potential side effects during the transition period are critical

Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone

While compounded semaglutide may be appropriate in rare, clinically justified situations, FDA-approved medications remain the preferred standard

Further exploration is required as certain patients have reported muscle pain with Semaglutide