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Postgrad Med J

Researchers report that compounded GLP-1 RA sourcing is highly variable

Both drugs were on the FDA drug shortage list, and both have FDA-approved branded versions (Ozempic, Wegovy, Mounjaro, Zepbound)

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These two peptides stimulate growth hormone release through two independent receptor pathways : CJC-1295 activates GHRH receptors the same pathway used by your body's natural growth hormone-releasing hormone Ipamorelin activates ghrelin receptors (GHS-R) an entirely separate signaling pathway on the pituitary Stimulating both pathways simultaneously produces a synergistic growth hormone response the combined GH output is significantly greater than the sum of each peptide individually