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It's important to understand that these medications follow a gradual dose escalation schedule to minimize side effects, particularly nausea and gastrointestinal discomfort

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Pharmacogn Mag (2017) 13(52):67782

And so you kind of have a branch point when you think of managing these conditions

doi:10.3748/wjg.v25.i33.4904 48

We report two female patients, aged 44 and 45 years, with long-standing CSU inadequately controlled on high-dose H1AH, who were initially prescreened for participation in a clinical trial with barzolvolimab