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Ozempics active ingredient, semaglutide, was derived from exendin-4, a peptide found in the venom of the Gila monster

Not unimportant, in the perioperative period, the use of GLP-1 and GIP/GLP-1 receptor agonists may be associated with an increased risk of regurgitation and aspiration of gastric contents into the lungs during induction of general anesthesia due to delayed emptying and retention of gastric contents

Semaglutide# Semaglutide is a selective GLP-1 receptor agonist with no amylin activity

In 2024 the Food and Drug Administration added cardiovascular risk as a reason to be prescribed the GLP-1 drug Wegovy, grounded in results from a major trial that showed fewer heart attacks, strokes, and cardiovascular deaths in adults with obesity or overweight and established heart disease

95% CI 95.23, 1.12), GLP-1 Ras/metformin (WMD: 33.89

The result is that GI effects that were prominent in week one diminish by week four, even though drug levels are actually higher by week four than week one